Caslin H.L, Cottam M.A., Piñon J.M.†, Boney L.Y. †, Hasty, A.H. Weight cycling induces innate immune memory in adipose tissue macrophages. Frontiers in Immunology. 2023 Jan 11; 13. doi: 10.3389/fimmu.2022.984859.

Winn N.C. *, Cottam M.A.*, Bhanot M., Caslin H.L., Garcia J.N., Arrojo E Drigo R, Hasty A.H. Weight cycling impairs pancreatic insulin secretion but does not perturb whole-body insulin action in diet-induced obese mice. Diabetes. 2022 Jul 8;db220161. doi: 10.2337/db22-0161.

Cottam M.A.*, Caslin H.L*, Winn N.C., Hasty A.H. Multiomics reveals persistence of obesity-associated immune cell phenotypes during weight loss and subsequent weight regain. Nature Communications. 2022 May 26;13(1):2950. doi: 10.1038/s41467-022-30646-4.

Caslin H.L, Abebayehu D., Pinette J.A., Ryan J.J. Not solely a metabolic by-product, lactate shapes immune cell fate and function. Frontiers in Physiology. 2021 Oct; 12. doi: 10.3389/fphys.2021.688485.

Caslin H.L*, Bhanot M.*, Bolus W.R., Hasty A.H. Adipose tissue macrophages: unique polarization and bioenergetics in obesity. Immunological Reviews. 2020; 00:1-13. doi: 10.1111/imr.12853.

Caslin H.L and Hasty A.H. Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity. Current Obesity Reports. 2019 Sep;8(3):210-219. doi: 10.1007/s13679-019-00344-2. Review.

Caslin H.L., Abebayehu D., Abdul Qayum A., Paez P.A., Hoeferlin L.A., Chalfant C.E., Ryan JJ. Lactic acid limits glycolysis and ATP availability effectively reducing LPS-induced cytokine production in mast cells and in vivo. Journal of Immunology. 2019 Jul 15;203(2):453-464. doi: 10.4049/jimmunol.1801005.

Abebayehu D., Spence A.J., Caslin H.L., Taruselli M.T., Kolawole E.M., Chumanevich A.P., Sell S., Oskeritzian C.A., Ryan J.J. Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo. Cellular Immunology. 2019 Jul;341:103918. doi: 10.1016/j.cellimm.2019.04.006. Epub 2019 Apr 12.

Caslin H.L., Taruselli M.T., Haque T.T., Pondicherry N., Baldwin E.A., Barnstein B.O., Ryan J.J. Inhibiting glycolysis and ATP production attenuates IL-33-mediated cytokine production in mast cells and IL-33-induced peritonitis. Frontiers in Immunology. 2018; 9. doi:10.3389/fimmu.2018.03026

Caslin H.L., Kiwanuka K.N., Haque T.T., Taruselli M.T., MacKnight H.P., Paranjape A., Ryan J.J. Controlling Mast Cell Activation and Homeostasis: Work Influenced by Bill Paul that Continues Today. Frontiers in Immunology. 2018 Apr; 9: 868. doi:10.3389/fimmu.2018.00868

Abebayehu D., Spence A.J., Abdul Qayum A. Taruselli M., McLeod J., Caslin H.L., Kolawole E., Ndaw V., Barnstein B.O., Oskertizian C.A., Ryan J.J. Lactic acid suppresses IL-33-mediated mast cell inflammatory responses via HIF-1 dependent miR-155 suppression. Journal of Immunology. 2016; 197(7):2909-17. doi: 10.4049/jimmunol.1600651

Hodgman, C.F. Hunt, R.M., Crane, J.C. Elzayat, M.T., LaVoy, E.C. (2023) A Scoping Review on the Effects of Physical Exercise and Fitness on Peripheral Leukocyte Energy Metabolism. Exerc Immunol Rev. 29:54-87 PMID: 37358364

Hunt, R., Elzayat, M., Laughlin, M., Markofski, M.M., LaVoy, EC. (2023) Characterization of Transitional Memory CD4+ and CD8+ T-cell Mobilization During and After an Acute Bout of Exercise. Frontiers in Sports and Active Living, https://doi.org/10.3389/fspor.2023.1120454

Crane, J., Gordon, M., Basen-Engquist, K., Ferrajoli, A., Markofski, M.M., Young, C., Fares, S., Simpson, R., LaVoy, E.C. (2023) Relationships between T-lymphocytes and physical function in adults with chronic lymphocytic leukemia: results from the HEALTH4CLL pilot study. European Journal of Haematology https://doi.org/10.1111/ejh.13958

Savage, H., Pareek, S., Lee, J., Ballaro, R., Minussi, D.C., Hayek, K., Sadullozoda, M., Lochmann, B., McQuade, J., LaVoy, E., Marmonti, E., Patel, H., Wang, G., Imanishi, M., Kotla, S., Abe, J., Schadler, K. (2023) Aerobic exercise alters the melanoma microenvironment and modulates ERK5 S496 phosphorylation. Cancer Immunology Research https://doi.org/10.1158/2326-6066.CIR-22-0465

Batatinha, H., Diak, D., Niemiro, G., Baker, F., Smith, K., Zúñiga, T., Mylabathula, P., Seckeler, M., Lau, B., LaVoy, E.C., Gustafson, M., Katsanis, E., Simpson, R.J. (2023) Human lymphocytes mobilized with exercise have an anti-tumor transcriptomic profile and exert enhanced graft-versus-leukemia effects in xenogeneic mice. Front Immunol https://doi.org/10.3389/fimmu.2023.1067369

Gupta P, Hodgman CF, Alvarez-Florez C, Schadler KL, Markofski MM, O'Connor D.P., LaVoy, E.C. (2022) Comparison of three exercise interventions with and without gemcitabine treatment on pancreatic tumor growth in mice: No impact on tumor infiltrating lymphocytes. Front Physiol. [https://doi:10.3389/fphys.2022.1039988]https://doi:10.3389/fphys.2022.1039988

Hodgman, C.F., LaVoy, E.C., Johnston, C.A., Obasi, E., Murillo R., Yan S., O’Connor D.P., McNeill, L. Reitzel, L.R., Hernandez, D.C. (2022) Measuring pro- and anti-inflammatory biomarkers among low-income Hispanic adults: a feasibility and pilot assessment. Health Behavior Research Vol. 5: No. 3. https://doi.org/10.4148/2572-1836.1143

Graff, R.M., Jennings, K., LaVoy, E.C., Warren, V., Macdonald, B., Park, Y., Markofski, M. (2022) T-cell counts in response to acute cardiorespiratory or resistance exercise in physically active or physically inactive older adults: A randomized crossover study. Journal of Applied Physiology [https://doi:10.1152/japplphysiol.00301.2021]https://doi:10.1152/japplphysiol.00301.2021

Gupta, P., Hodgman, C.F., Schadler, K.L., LaVoy, E.C. (2022) Effect of exercise on pancreatic cancer patients during treatment: A scoping review of the literature. Supportive Care in Cancer https://doi.org/10.1007/s00520-022-06925-7

Markofski, M.M., Jennings, K., Hodgman, C.F., Warren, V.E., LaVoy, E.C. (2021) Physical activity during the SARS-CoV-2 pandemic is linked to better mood and emotion. Stress & Health https://doi.org/10.1002/smi.3111

Elzayat, M.T., Markofski, M.M., Simpson, R.J., Laughlin, M., LaVoy, E.C (2021) No effect of acute eccentric resistance exercise on immune responses to Influenza vaccination in older adults: a randomized control trial. Frontiers in Physiology https://doi.org/10.3389/fphys.2021.713183

Reesor-Oyer, L., Murillo, R., LaVoy, E.C., O’Connor, D.P., Liu, Y., Hernandez, D.C. (2021) The role of leisure time physical activity and sedentary behavior in the income-overweight/obesity relationship. International Journal of Environmental Research and Public Health https://doi.org/10.3390/ijerph18063127

Graff, R., Jennings, K., Davies, N., Carrillo, A., LaVoy, E.C., Ryan, E.J., Markofski, M. (2021) A short-term paleolithic dietary intervention does not alter adipokines linked to adiposity. International Journal of Exercise Science https://digitalcommons.wku.edu/ijes/vol14/iss2/3

LaVoy, E.C., Palmer, C.A., So, C., Alfano, C.A. (2020) Bidrectional relationships between sleep and biomarkers of stress and immunity in youth. International Journal of Psychophysiology https://doi.org/10.1016/j.ijpsycho.2020.10.010

Kunz, H.E., Agha, N.H., LaVoy, E.C., Hussain, M., Smith, K.A., Mylabathula, P., Diak, D., Baker, F.L., O'Connor, D. P., Bond, R.A., Katsanis, E., Bollard, C.M. Simpson, R.J. (2020) The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T-cells: implications for cellular therapy and the anti-viral immune effects of exercise. Cell Stress and Chaperones https://doi.org/10.1007/s12192-020-01136-7

Lee, J., Hong, J. Umetani, M., LaVoy, E.C., Kim, J., Park, Y. (2020) Vascular protection by exercise in obesity: inflammasome-associated mechanisms. Medicine & Science in Sports & Exercise https://doi.org/10.1249/MSS.0000000000002419

(Selected publications from last five years. Full list in CV)
Graff RM, Jennings K, LaVoy EC, Warren VE, Macdonald BW, Park Y, Markofski MM. T-cell responses to acute cardiorespiratory or resistance exercise in cohorts of physically active or physically inactive older adults: A randomized complete crossover. J Appl Physiol. 2022 Jul 1;133(1):119-129. PMID: 35616304

Markofski MM, Jennings K, Hodgeman CF, Warren VE, and LaVoy EC. Physical activity during the SARS-CoV-2 pandemic is linked to better mood and emotion. Stress and Health. 2022 Aug 28(3):490-499. PMID: 34775682

Markofski MM and Flynn MG. Elevated circulating CD16+ monocytes and TLR4+ monocytes in older adults with multiple cardiometabolic disease risk factors. Exp Gerontol 2021 Oct 15(154):111530. PMID: 34450235

Elzayat MT, Markofski MM, Simpson RJ, Laughlin M, LaVoy E. No Effect of Acute Eccentric Resistance Exercise on Immune Responses to Influenza Vaccination in Older Adults: a Randomized Control Trial. Front in Physiol. 2021 Aug 12(12). PMID: 34456752.

Borack BS, Dickinson JM, Fry CS, Reidy PT, Markofski MM, Deer RR, Jennings K, Volpi E, Rasmussen BB. Effect of the lysosomotropic agent chloroquine on mTORC1 activation and protein synthesis in human skeletal muscle. Nutr & Metab. 2021 Jun 12;18(1):61. PMID: 34118944

Graff RM, Jennings K, Davies NA, Carrillo AE, LaVoy EC, Ryan EJ, and Markofski MM. (2021) A Short-Term Paleolithic Dietary Intervention Does Not Alter Adipokines Linked to Adiposity. Int J Exerc Sci. 2021 14(2):113-122. PMID: 34055149

Randolph AC, Markofski MM, Rasmussen BB, Volpi E. Effect of essential amino acid supplementation and aerobic exercise on insulin sensitivity in healthy older adults: A randomized clinical trial. Clin Nutr. 2020 May;39(5):1371-1378. PubMed PMID: 31307843.

Agha NH, Mehta SK, Rooney BV, Laughlin MS, Markofski MM, Pierson DL, Katsanis E, Crucian BE, Simpson RJ. Exercise as a countermeasure for latent viral reactivation during long duration space flight. FASEB J. 2020 Feb;34(2):2869-2881. PubMed PMID: 31908052.

Heenan KA, Carrillo AE, Fulton JL, Ryan EJ, Edsall JR, Rigopoulos D, Markofski MM, Flouris AD, Dinas PC. Effects of Nutrition/Diet on Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis. Nutrients. 2020 Sep 10;12(9) PubMed PMID: 32927664.

Mylabathula PL, Li L, Bigley AB, Markofski MM, Crucian BE, Mehta SK, Pierson DL, Laughlin MS, Rezvani K, Simpson RJ. Simulated microgravity disarms human NK-cells and inhibits anti-tumor cytotoxicity in vitro. Acta Astronautica. 2020 Sep; 174 (21-40). https://doi.org/10.1016/j.actaastro.2020.03.023

Cho D, Basen-Engquist K, Acquati C, Pettaway C, Ma H, Markofski M, Li Y, Canfield SE, Gregg J, McNeill LH. Cultural Adaptation of Evidence-Based Lifestyle Interventions for African American Men With Prostate Cancer: A Dyadic Approach. Am J Mens Health. 2020 Nov-Dec; 14(6):1557988320945449. PubMed PMID: 33148111.

Agha NH, Baker FL, Kunz HE, Spielmann G, Mylabathula PL, Rooney BV, Mehta SK, Pierson DL, Laughlin MS, Markofski MM, Crucian BE, Simpson RJ. Salivary antimicrobial proteins and stress biomarkers are elevated during a 6-month mission to the International Space Station. J Appl Physiol (1985). 2020 Feb 1;128(2):264-275. PubMed PMID: 31751178.

Markofski MM, Jennings K, Dolan C, Davies NA, LaVoy EC, Ryan EJ, Carrillo AE. Single-Arm 8-Week Ad Libitum Self-Prepared Paleo Diet Reduces Cardiometabolic Disease Risk Factors in Overweight Adults. American Journal of Lifestyle Medicine. 2019 August 02. https://doi.org/10.1177/1559827619866157

Markofski MM, Jennings K, Timmerman KL, Dickinson JM, Fry CS, Borack MS, Reidy PT, Deer RR, Randolph A, Rasmussen BB, Volpi E. Effect of aerobic exercise training and essential amino acid supplementation for 24 weeks on physical function and muscle metabolism in healthy, independent older adults: a randomized clinical trial. J Gerontol Med Sci. Epub 2019 Sept 15;74(10):1598-1604. PMID: 29750251

Brightwell C, Markofski MM, Moro T, Fry C, Porter C, Volpi E, Rasmussen B. Moderate Intensity Aerobic Exercise Improves Skeletal Muscle Quality in Older Adults. Translational Sports Med. 2019 April 2(3):109-119. PMID: 31123725

Carrillo AE, Markofski MM, Flynn MG. Elevated inflammatory status and increased risk of chronic disease in chronological aging: Inflamm-aging or inflamm-inactivity? Aging and Disease. 2019 Feb 1;10(1):147-156. PMID: 30705775

Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ. β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018 Nov;74:143-153. PMID: 30172948

Gupta P, Bigley AB, Markofski M, Laughlin M, LaVoy EC. Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 2018 Jul;71:81-92. PMID: 29656052

Lee J, Hong J, Umetani M, LaVoy E, Kim J, *Park Y. Vascular protection by exercise in obesity: inflammasome-associated mechanisms. Med Sci Sports Exerc. 2020. (In Print)

Hong J, Hong SK, Lee J, Park JY, Eriksen JL, Rooney BV, and *Park Y Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer’s disease: role of the P2Y2 receptor and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol. 2020. Jun 1;318(6):H1559-H1569. doi: 10.1152/ajpheart.00129.2020.

Kwon I, Kim JS, Shin CH, Park Y, Kim JH. Associations Between Skeletal Muscle Mass, Grip Strength, and Physical and Cognitive Functions in Elderly Women: Effect of Exercise with Resistive Theraband.J Exerc Nutrition Biochem. 2019 Sep 30;23(3):50-55

Jung J, Seo DI, Park Y, So WY. Echocardiography evaluation of left ventricular diastolic function in elderly women with metabolic syndrome. Open Medicine. 2019 Aug. doi: 10.1515/med-2019-0073

Son Y, Kim K, Jeon S, Kang M, Lee S, *Park Y. Response to: Comment on "Effect of Exercise Intervention on Flow-Mediated Dilation in Overweight and Obese Adults: Meta-Analysis" Int J Vasc Med. 2019 Feb 5;2019:2470581. doi: 10.1155/2019/2470581

Lee J, Lee Y, LaVoy E, Umetani M, Hong J, *Park Y. Physical Activity Protects NLRP3 inflammasome-induced Vascular Dysfunction in Obesity. Physiol. Rep. 2018. Jun;6(12):e13738. doi: 10.14814/phy2.13738.

Hong J, Kim K, Park E, Lee J, Markofski MR, Marrelli SP, and *Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in atherosclerotic mesenteric arteries. Sci Rep. 2018 8:7938 | DOI:10.1038/s41598-018-26188-9. 2018

Lee J, Lee R, Hwang MH, Hamilton MT, *Park Y. The effects of exercise on vascular endothelial function in type 2 diabetes: A Systematic Review and Meta-analysis. Diabetol Metab Syndr. 2018 Mar 6;10:15. doi: 10.1186/s13098-018-0316-7. 2018

Lee J, Lee S, Zhang H, Hill MA, Zhang C, *Park Y. Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mice heart. PLoS ONE. 2017 Nov 2;12(11):e0187189. doi: 10.1371/journal.pone.0187189. 2017

Son Y, Kim K, Jeon S, Kang M, Lee S, *Park Y. Effect of exercise intervention on flow-mediated dilation in overweight and obese adults: Meta-analysis. Int J Vasc Med. 2017;7532702. doi: 10.1155/2017/7532702. 2017

So WY, Lee SY, Park Y, Seo DI. Effects of 4 weeks of horseback riding on anxiety, depression, and self-esteem in children with attention deficit hyperactivity disorder. J Mens Health. 2017– 13(2):e1-e7; September 28, 2017

Hong J, Kim K, Kim J, *Park Y. The role of endoplasmic reticulum stress in cardiovascular disease and exercise. Int J Vasc Med. 2017:2049217. doi: 10.1155/2017/2049217. 2017

Chen X, Zhang H, Hill MA, Zhang C, *Park Y. Regulation of coronary endothelial function affected by feedback among TNF-α, LOX-1 and adiponectin in ApoE knockout mice. J Vasc Res. 52(6):372-82. 2016

Kim JH and *Park Y. The combined effects of phytochemicals and exercise on fatty acid oxidation. J Exerc Nutrition Biochem. 20(4);20-26. 2016

Ghosh P, Behnke BJ, Stabley JN, Kilar CR, Park Y, Muller-Delp JM, Alwood JS, Shirazi-Fard Y, Schreurs NS, Globus RK, Delp MD. Effects of high-LET radiation and hindlimb unloading on skeletal muscle resistance artery vasomotor properties in mice. Radiation Research. Mar;185(3):257-66. 2016

Kunz H, Bishop NC, Spielmann G, Pistillo M, Reed J, Ograjsek T, Park Y, Mehta SK, Pierson DL, Simpson RJ. Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise. Eur J Appl Physiol. 115(5):1015-27. 2015

Park Y, Prisby RB, Lesniewski LA, Donato AJ, Delp MD. Effects of aging and exercise training on Angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles, J Appl Phsiol., Oct;113(7):1091-100. 2012

*Park Y, Booth FW, Lee S, Laye MJ, and Zhang C. Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice. J Physiol (Lond). Sep;1;590(Pt 17):4255-68. 2012

Lee S, Park Y, Zhang C. exercise training prevents coronary endothelial dysfunction in type 2 diabetic mice. Am. J. Biomed. Sci 3(4): 241-252. 2011

Lee S, Park Y, Dellsperger KC, Zhang C. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. Aug;301(2):H306-14. 2011

Park Y, Yang J, Zhang H, Chen X and Zhang C. Role of PAR2 in the regulation of TNF-α-induced endothelial dysfunction in type 2 diabetic mice. Basic Res Cardiol. Jan;106(1):111-23. 2011

Zhang H, Park Y, Liu Y and Zhang C. Coronary and aortic endothelial function affected by feedback between adiponectin and TNF-α in type 2 diabetic mice. Arterioscler Thromb Vasc Biol. Nov;30(11):2156-63. 2010

Yang J, Park Y, Zhang H, Gao X, Wilson E, Zimmer W, Abbott L and Zhang C. Role of MCP-1 in tumor necrosis factor alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 297(4):H1208-16. 2009

Yang J+, Park Y+, Zhang H, Xu X, Laine GA, Dellsperger KC and Zhang C (+Co-first authors). Feed-forward signaling of TNF-α and NFκB via IKKβ pathway induces insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 296(6):H1850-8, 2009

Park Y, Capobianco S, Gao X, Falck JR, Dellsperger KC and Zhang C. Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol. 295(5):H1982-8, 2008

Zhang C, Park Y, Picchi A and Potter BJ. Maturation-induced endothelial dysfunction via vascular inflammation in diabetic mice. Basic Res Cardiol. 103(5):407-16. 2008

Gao X, Park Y, Capobianco S, Yang J, Zhang H, Picchi A and Zhang C.. Role of TNF alpha in prediabetic metabolic syndrome induced endothelial dysfunction. 8th World Congress for MICROCIRCULATION (Ed. Julian H Lombard). MEDIMOND S.r.l., International Proceedings., H815R9145: P179-185. 2007

Selected Funded Grants 
ACTIVE RESEARCH SUPPORT
External

NASA (NRA- NNJ16ZSA001N-SRHHC). Role: Co-Investigator (PI: Michael Delp). “Radiation, Simulated Weightlessness and Countermeasures: Effects on Cerebral and Coronary Vascular Function and Structure.” June 2018 – May 2021.

Korea Institute of Robot and Convergence (KIRO). Role: Co-Investigator (PI: Beom-Chan Lee). “Developing and Assessing Wearable Technologies to Predict and Prevent Falls.” June 2017 - December 2022.

American College of Sports Medicine (ACSM, Foundation Doctoral Student Research Grant) Role: Supervisor. (PI: Junyoung Hong, doctoral student). “The effect of exercise on purinergic receptor-mediated cerebrovascular dysfunction in Alzheimer’s Disease.”July 2018 – June 2019.

COMPLETED RESEARCH SUPPORT
External

CardioVascular Research Foundation. Role: Principal Investigator, “The Effect of Aerobic Exercise on Coronary Arterial Endothelial Function in ApoE-/- Mice – The Role of Liver X Receptor (LXR) and Uncoupling Protein-2 (UCP-2).” June 2015 – January 2017.