List of recent publications
* LaVoy, E.C., Arlinghaus, K., Rooney, B., Gupta, P., Atkinson, R., and C. Johnston. High Adenovirus 36 seroprevalence among a population of Hispanic American youth. Int J Adolesc Med Health- in press
*Wardle, M.C., Lopez-Gamundi, P., and E.C. LaVoy. (2018) Effects of an acute bout of physical exercise on reward functioning in healthy adults. Physio and Behav 194:552-559.
# Rooney, B.V., Bigley, A., LaVoy, E., Laughlin, M., Pedlar, C., and R. J. Simpson. (2018) Lymphocytes and monocytes egress peripheral blood within minutes after cessation of steady state exercise: A detailed temporal analysis of leukocyte extravasation. Physio and Behav 194:260-267
#Lee, J., Lee, Y., LaVoy, E.C., Umetani, M., Hong, J. and Y. Park. (2018) Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice. Physiol. Reports 6(12):e13738.
*#Gupta, P., Bigley, A., Markofski, M., Laughlin, M., and E.C. LaVoy. (2018) Autologous serum collected 1h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 71:81-92
# Serajian, A., Nourshahi, M., LaVoy, E., and D. Eliaspour. (2017) Decrease in baseline values of inflammatory mediators and improvement in muscular performance after 4-weeks fish oil supplementation. Razi Journal of Medical Sciences, 24 (160)
*LaVoy, E.C., Hussain, M., Reed, J. Kunz, H., Pistillo, M., Bigley, A. and R. J. Simpson. (2017) T-cell redeployment and intracellular cytokine expression following exercise: effects of exercise intensity and cytomegalovirus infection. Physiology Reports, 5 (1)
*LaVoy E.C., Fagundes C.P., and R. Dantzer. (2016) Exercise, inflammation, and fatigue in cancer survivors. Exercise Immunology Review, 22 82-93
Simpson, R.J., Bigley, A.B., Spielmann, G., E.C. LaVoy, Kunz, H., and C.M. Bollard. (2016) Human cytomegalovirus infection and the immune response to exercise. Exercise Immunology Review, 22 8-27.
# Silveira, S.L., LaVoy, E.C., and C.A. Johnston. (2016) Assisting the novice in lifestyle change. American Journal of Lifestyle Medicine, 10 (3)
*LaVoy E.C., Bollard C.M., Hanley P.J., Blaney J.W., O’Connor D.P., Bosch J.A., and R.J. Simpson. (2015) A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic T-cells from healthy adults. Exercise Immunology Review, 21,144-53.
*LaVoy E.C., Bollard C.M., Hanley P.J., O’Connor D.P., Lowder T.W., Bosch J.A., and R.J. Simpson. (2015) A Single Bout of Dynamic Exercise by Healthy Adults Enhances the Generation of Monocyte-Derived-Dendritic Cells. Cellular Immunology 295, 52-59.
Brown, F.F., Bigley, A.B., Ross, J.S., LaVoy, E.C., Simpson, R.J., and S.D.R. Galloway. (2015) T-lymphocyte populations following a period of high volume training in female soccer players. Physiology and Behavior
*LaVoy, E.C., Bigley, A.B., Spielmann, G., Rector, J.L., Morrison, M.R., O’Connor, D.P. and R.J. Simpson. (2014) CMV amplifies T-cell redeployment to acute exercise independently of HSV-1 serostatus. Medicine and Science in Sports and Exercise, 46, 257-267.
Spielmann, G. Bollard, C.M., Bigley, A.B., Hanley, P.J., Blaney, J.W., LaVoy, E.C., Pircher, H. and R.J. Simpson. (2014) The effects of age and latent cytomegalovirus infection on the redeployment of CD8+ T cell subsets in response to acute exercise in humans. Brain Behavior and Immunity, 39, 142-151.
* denotes first/senior author, # denotes student manuscript
(selected publications. Full list in CV)
Graff RM, Kunz HE, Agha NH, Baker FL, Laughlin M, Bigley AB, Markofski MM, LaVoy EC, Katsanis E, Bond RA, Bollard CM, Simpson RJ. β2-Adrenergic receptor signaling mediates the preferential mobilization of differentiated subsets of CD8+ T-cells, NK-cells and non-classical monocytes in response to acute exercise in humans. Brain Behav Immun. 2018 Aug 30. [Epub ahead of print] PMID: 30172948
Gupta P, Bigley AB, Markofski M, Laughlin M, LaVoy EC. Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 2018 Jul;71:81-92. PMID: 29656052
Hong J, Kim K, Park E, Lee J, Markofski MM, Marrelli SP, Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in mesenteric arteries in atherosclerosis. Sci Rep. 2018 May 21;8(1):7938. PMID: 29784903
Markofski MM, Jennings K, Timmerman KL, Dickinson JM, Fry CS, Borack MS, Reidy PT, Deer RR, Randolph A, Rasmussen BB, Volpi E. Effect of aerobic exercise training and essential amino acid supplementation for 24 weeks on physical function and muscle metabolism in healthy, independent older adults: a randomized clinical trial. J Gerontol Med Sci. Epub 2018 May 10. PMID: 29750251
Carrillo AE, Markofski MM, Flynn MG. Elevated inflammatory status and increased risk of chronic disease in chronological aging: Inflamm-aging or inflamm-inactivity? Aging and Disease. 2018 Dec; 9(6):xxx-xx
Agha NH, Baker FL, Kunz HE, Graff R, Azadan R, Dolan C, Laughlin MS, Hosing C, Markofski MM, Bond RA, Bollard CM, Simpson RJ. Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor. Brain Behav Immun. 2018 Feb;68:66-75. Epub 2017 Oct 7. PMID: 29017969
Arlinghaus KR, Markofski MM, Johnston CA. Reducing anxiety to increase exercise in individuals with decreased lung capacity. Am J Lifestyle Med. 2017 April;11(4):307-309.
Reidy PT, Borack MS, Markofski MM, Dickinson JM, Fry CS, Deer RR, Volpi E, Rasmussen BB. Post-absorptive muscle protein turnover affects resistance training hypertrophy. Eur J Appl Physiol. 2017 May;117(5):853-866. PMID: 28280974
Borack MS, Reidy PT, Husaini SH, Markofski MM, Deer RR, Richison AB, Lambert BS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men. J Nutr. 2016 Dec; 146(12):2468-2475. PMID: 27798330
Reidy PT, Borack MS, Markofski MM, Dickinson JM, Deer RR, Husaini SH, Walker DK, Igbinigie S, Robertson SM, Cope MB, Mukherjea R, Hall-Porter JM, Jennings K, Volpi E, Rasmussen BB. Protein supplementation has minimal effect on muscle adaptations during resistance exercise training in young men: a double-blind randomized clinical trial. J Nutr. 2016 Sept; 146(9):1660-9. PMID: 27466602
Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon-Jones D, Reidy PT, Sheffield-Moore M, Timmerman KL, Rasmussen, BB, and Volpi E. Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol. 2015 May;65:1-7. PMID: 25735236
Timmerman KL, Amonette WE, Markofski MM, Ansinelli HA, Gleason EA, Rasmussen BB, and Mossberg KA. Impaired IL-6 and IL-10 response to exercise in patients with traumatic brain injury. Eur J Appl Physiol. 2015 Jan;115(1):111-8.
Markofski MM, Flynn MG, Carrillo AE, Armstrong C, Campbell WW, and Sedlock, DA. Exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage with and without weight loss in overweight and obese adults. Eur J Appl Physiol. 2014 Aug;114(8):1737-48.
Markofski MM and Braun WA. Influence of menstrual cycle on indices of contraction-induced muscle damage. J Strength Cond Res. 2014 Sep;28(9):2649.
Markofski MM, Carrillo AE, Timmerman KL, Jennings K, Coen PM, and Flynn MG. Exercise training modifies ghrelin and adiponectin concentrations and is related to inflammation in older adults. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):675-81.
Drummond MJ, Timmerman KL, Markofski MM, Walker DK, Dickinson JM, Jamaluddin M, Brasier AR, Rasmussen BB, Volpi E. Short-term bed rest increases TLR4 and IL-6 expression in skeletal muscle of older adults. Am J Physiol Regul Integr Comp Physiol. 2013 Aug 1;305(3):R216-23.
Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. 2013 Jun;32(3):375-81
Drummond MJ, Dickinson JM, Fry CS, Walker DK, Gundermann DM, Reidy PT, Timmerman KL, Markofski MM, Paddon-Jones D, Rasmussen BB, Volpi E. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1113-22.
Carrillo AE, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects. Eur J Appl Physiol. 2012 Aug;112(8):3045-52
Markofski MM and Volpi E. Protein metabolism in women and men: similarities and disparities. Curr Opin Clin Nutr Metab Care. 2011 Jan;14(1):93-7.
Coen PM, Flynn MG, Markofski MM, Pence BD, Hannemann RE. Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population. Metabolism. 2010 Dec;59(12):1775-83.
Lee J, Lee Y, LaVoy E, Umetani M, Hong J, *Park Y. Physical Activity Protects NLRP3 inflammasome-induced Vascular Dysfunction in Obesity. Physiol. Rep. 2018. Jun;6(12):e13738. doi: 10.14814/phy2.13738.
Hong J, Kim K, Park E, Lee J, Markofski MR, Marrelli SP, and *Park Y. Exercise ameliorates endoplasmic reticulum stress-mediated vascular dysfunction in atherosclerotic mesenteric arteries. Sci Rep. 2018 8:7938 | DOI:10.1038/s41598-018-26188-9. 2018
Lee J, Lee R, Hwang MH, Hamilton MT, *Park Y. The effects of exercise on vascular endothelial function in type 2 diabetes: A Systematic Review and Meta-analysis. Diabetol Metab Syndr. 2018 Mar 6;10:15. doi: 10.1186/s13098-018-0316-7. 2018
Lee J, Lee S, Zhang H, Hill MA, Zhang C, *Park Y. Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mice heart. PLoS ONE. 2017 Nov 2;12(11):e0187189. doi: 10.1371/journal.pone.0187189. 2017
Son Y, Kim K, Jeon S, Kang M, Lee S, *Park Y. Effect of exercise intervention on flow-mediated dilation in overweight and obese adults: Meta-analysis. Int J Vasc Med. 2017;7532702. doi: 10.1155/2017/7532702. 2017
So WY, Lee SY, Park Y, Seo DI. Effects of 4 weeks of horseback riding on anxiety, depression, and self-esteem in children with attention deficit hyperactivity disorder. J Mens Health. 2017– 13(2):e1-e7; September 28, 2017
Hong J, Kim K, Kim J, *Park Y. The role of endoplasmic reticulum stress in cardiovascular disease and exercise. Int J Vasc Med. 2017:2049217. doi: 10.1155/2017/2049217. 2017
Chen X, Zhang H, Hill MA, Zhang C, *Park Y. Regulation of coronary endothelial function affected by feedback among TNF-α, LOX-1 and adiponectin in ApoE knockout mice. J Vasc Res. 52(6):372-82. 2016
Kim JH and *Park Y. The combined effects of phytochemicals and exercise on fatty acid oxidation. J Exerc Nutrition Biochem. 20(4);20-26. 2016
Ghosh P, Behnke BJ, Stabley JN, Kilar CR, Park Y, Muller-Delp JM, Alwood JS, Shirazi-Fard Y, Schreurs NS, Globus RK, Delp MD. Effects of high-LET radiation and hindlimb unloading on skeletal muscle resistance artery vasomotor properties in mice. Radiation Research. Mar;185(3):257-66. 2016
Kunz H, Bishop NC, Spielmann G, Pistillo M, Reed J, Ograjsek T, Park Y, Mehta SK, Pierson DL, Simpson RJ. Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise. Eur J Appl Physiol. 115(5):1015-27. 2015
Park Y, Prisby RB, Lesniewski LA, Donato AJ, Delp MD. Effects of aging and exercise training on Angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles, J Appl Phsiol., Oct;113(7):1091-100. 2012
*Park Y, Booth FW, Lee S, Laye MJ, and Zhang C. Physical activity opposes coronary vascular dysfunction induced during high fat feeding in mice. J Physiol (Lond). Sep;1;590(Pt 17):4255-68. 2012
Lee S, Park Y, Zhang C. exercise training prevents coronary endothelial dysfunction in type 2 diabetic mice. Am. J. Biomed. Sci 3(4): 241-252. 2011
Lee S, Park Y, Dellsperger KC, Zhang C. Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. Aug;301(2):H306-14. 2011
Park Y, Yang J, Zhang H, Chen X and Zhang C. Role of PAR2 in the regulation of TNF-α-induced endothelial dysfunction in type 2 diabetic mice. Basic Res Cardiol. Jan;106(1):111-23. 2011
Zhang H, Park Y, Liu Y and Zhang C. Coronary and aortic endothelial function affected by feedback between adiponectin and TNF-α in type 2 diabetic mice. Arterioscler Thromb Vasc Biol. Nov;30(11):2156-63. 2010
Yang J, Park Y, Zhang H, Gao X, Wilson E, Zimmer W, Abbott L and Zhang C. Role of MCP-1 in tumor necrosis factor alpha-induced endothelial dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 297(4):H1208-16. 2009
Yang J+, Park Y+, Zhang H, Xu X, Laine GA, Dellsperger KC and Zhang C (+Co-first authors). Feed-forward signaling of TNF-α and NFκB via IKKβ pathway induces insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 296(6):H1850-8, 2009
Park Y, Capobianco S, Gao X, Falck JR, Dellsperger KC and Zhang C. Role of EDHF in type 2 diabetes-induced endothelial dysfunction. Am J Physiol Heart Circ Physiol. 295(5):H1982-8, 2008
Zhang C, Park Y, Picchi A and Potter BJ. Maturation-induced endothelial dysfunction via vascular inflammation in diabetic mice. Basic Res Cardiol. 103(5):407-16. 2008
Gao X, Park Y, Capobianco S, Yang J, Zhang H, Picchi A and Zhang C.. Role of TNF alpha in prediabetic metabolic syndrome induced endothelial dysfunction. 8th World Congress for MICROCIRCULATION (Ed. Julian H Lombard). MEDIMOND S.r.l., International Proceedings., H815R9145: P179-185. 2007
Selected Funded Grants
ACTIVE RESEARCH SUPPORT
NASA (NRA- NNJ16ZSA001N-SRHHC). Role: Co-Investigator (PI: Michael Delp). “Radiation, Simulated Weightlessness and Countermeasures: Effects on Cerebral and Coronary Vascular Function and Structure.” June 2018 – May 2021.
Korea Institute of Robot and Convergence (KIRO). Role: Co-Investigator (PI: Beom-Chan Lee). “Developing and Assessing Wearable Technologies to Predict and Prevent Falls.” June 2017 - December 2022.
American College of Sports Medicine (ACSM, Foundation Doctoral Student Research Grant) Role: Supervisor. (PI: Junyoung Hong, doctoral student). “The effect of exercise on purinergic receptor-mediated cerebrovascular dysfunction in Alzheimer’s Disease.”July 2018 – June 2019.
COMPLETED RESEARCH SUPPORT
CardioVascular Research Foundation. Role: Principal Investigator, “The Effect of Aerobic Exercise on Coronary Arterial Endothelial Function in ApoE-/- Mice – The Role of Liver X Receptor (LXR) and Uncoupling Protein-2 (UCP-2).” June 2015 – January 2017.